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​Diablo 2 Resurrected 2.4 New Plague Runeword Guide

The Plague Runeword is a Weapon Runeword in Diablo 2 Resurrected Patch 2.4 and Ladder Season, available only to players with characters in the Ladder Season One,  which was released in April 28, 2022. In this guide, we'll introduce you to the details of the Plague Runeword, including its pros and cons, stats, runes, changes, and more.

D2R 2.4 Plague Runeword Strengths and Weaknesses


Better bandwidth for reducing resistances for four attack types, making it useful for groups.

The only Runeword that does Lower Resist, the only curse that can break Poison immunity.

Cleansing Aura is extremely valuable for certain areas where Poison and Curses are a constant threat.

Other good melee bonuses such as Open Wounds and Deadly Strike.

While Cham is one of the highest-level Runes, it's not in high demand.


Not useful as a main weapon for one of the most common Poison-focused builds, the Poison/Plague Javazon

Not as useful as a weapon with Conviction for reducing Fire, Cold, or Lightning.

No actual bonuses to Poison damage.

D2R 2.4 Plague Runeword Stats

20% Chance to cast level 12 Lower Resist when struck

25% Chance to cast level 15 Poison Nova on striking

Level 13-17 Cleansing Aura When Equipped (varies)

+1-2 All Skills

+20% Increased Attack Speed

+220-320% Enhanced Damage (varies)

-23% To Enemy Poison Resistance

0.3% (0-29.7) Deadly Strike (Based on Character Level)

+25% Chance of Open Wounds

Freezes Target +3

D2R 2.4 Plague Runeword Changes

Old Plague runes: Cham, Fal, and Um, new Plague runes: Cham, Shael, and Um.

Old Plague: +260-380% damage to demons, new Plague: +220-320% enhanced damage.

Old Plague: 0.3% (0-29.7) Deadly Strike, new Plague: 0.375-37.125% Deadly Strike.

20% Increased Attack Speed added in new Plague.

Adds 5-30 Fire Damage and +10 to Strength are removed in the new Plague.

How To Get Plague Ladder Runeword In D2R 2.4

To make the Plague Runeword in Diablo 2 Resurrected, you need to acquire the three runes Cham, Shael, and Um first, and then place them in order. The Cham can be found in Hell Secret Cows, Act 4 Hell and above, the Shael can be found in Nightmare+ Countess, Normal Hellforge and Secret Cows, Act 5 Normal and above, the Um can be found in Hell Countess, Nightmare+ Hellforge and Secret Cows, Act 4 Nightmare and above.

How to Use Plague Runeword in D2R 2.4

Due to the Cham rune, Plague can be used from level 67. Plague is very useful for Assassins when made with a Claw Weapon. This is a very effective weapon for a Phoenix Strike-based build or a Kicksin Build and when combined with Chaos the Whirlwind Assassin.

In a Fanged Knife, Plague might be a good choice for a Poison Necromancer build. The + All Skills, Lower Resist and lower Enemy Poison Resist will all boost the damage of Poison Nova.

You can also pair this in a sword with a rabies druid to improve the effectiveness of the poison damage, the best base is an Elite sword, which provides high damage.

For mercenaries, it is the best option to use it on Act 5 Barbarian mercenary, because when he gets hit, there is a chance to trigger the lower resistance to the enemy.

These things you need to know about the Plague Runewords. If you haven't made Plague in the D2R Ladder Season One, you can buy it directly here. MMOSO offers all D2R Ladder Items For Sale at low prices, welcome you to place an order!




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